Before the actual ketamine sessions, individuals typically engage in preparatory psychotherapy sessions. These sessions help establish a therapeutic relationship, set intentions for the ketamine experience, and provide coping strategies for navigating challenging emotions.

During the ketamine sessions, the client is provided with an eyeshade and headphones playing ambient music. The client then may sit or lie down. The client and guide will confirm the appropriate dosage as prescribed and the client will take the medication orally which can be in the form of quick dissolve tablets or wax troches. The main thrust of the medicine journey lasts about 60-90 minutes, during which the client typically lays still and follows their internal experience. Most people describe the ketamine journey as relaxed, with a reduction of the usual mental chatter. Some people experience mental imagery while others experience more of an emotional or somatic experience. Challenging material can arise and the guide remains present to provide safety , reassurance, and assistance in moving through any challenging material. The sessions conclude with a brief period of processing and reflection on the experience.

Following each ketamine session, there are integration sessions where individuals discuss and process their experiences with a therapist. These sessions aim to help individuals integrate insights gained during the ketamine experience into their daily lives.